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10 Best Ergonomic Mouses For Large Hands & Their Reviews

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Tim Rhodes

For those of us blessed with big extremities, finding the right office tech can be quite challenging, and a true techie would value the importance of an ergonomic mouse for large hands.

Computer mouses have come a long way, and it has gradually improved from the traditional wired mouse to modern Bluetooth ones. 

Nowadays, features such as the ease of use and the comfort it can give, are what consumers mainly look for when buying this product, as it has become an essential tool, not only for everyday work but also for leisure. 

The increasing demand for ergonomic mouses, made for people who spend a lot of time using a computer, shows that the market is ready to give you several best choices, to relieve the fatigue you’ve been feeling lately.

Ergonomic mouses are available in different models, to help users reduce the numbness and the stress your arms are taking in.

If you are looking for the perfect ergonomic mouse for large hands, then you may want to continue reading, and you’ll find your perfect match!

1. AUTLEY Wireless Vertical Mouse

AUTLEY mouse
Considered to be one of the best mouses in the market now, ‘AUTLEY’s Wireless Vertical Mouse’ may be the right one for you! 

With more than a hundred, 5-star reviews on Amazon, there’s no doubt that this mouse has something to offer. 

It’s primarily made for people with large hands so, that your wrist will not get too strained.

Aside from its battery life of 12 to 20 days when used moderately after fully charging it, the ‘Silent Click’ feature is what makes this product special. 

This means, that you won’t distract your seatmate at the library with a clicking sound, or your office mate tired from having to hear left and right, clicking sounds, from your previous mouse.

It doesn’t only have one level adjustable ‘Dots Per Inch (DPI)’ but three DPI Levels, from 800 up to 1600, that will enable you to work efficiently and to improve productivity.

Be ready for some adjustments, considering that you hold it with four fingers on one side and your thumb on the other, to give you a nice hand angle and a comfortable wrist position and with its vertical feel, you won’t even notice that you have used the product for a long time!

You can easily conserve its life capacity, since, it sleeps after a few minutes of inactivity because it’s powered by a battery, so don’t worry about having to charge it now and then.

This piece of joy is a must-have!

Pros & Benefits:

  • Automatic power-saving mode
  • Responds quickly
  • Rough texture for grip but smooth & soft surface
  • Easy to navigate


2. Logitech M510 Wireless Computer Mouse

Logitech mouse
Selected as Amazon’s choice for large mouses, ‘Logitech’s M510 Wireless Computer Mouse’ is a must-have item that has a hand-friendly shape, that helps you power through your workflow! 

Not only does it provides you the perfect fit sculpted for comfortable finger support and smooth rubber grips, but its customizable buttons will also do exactly what you want them to do, just like moving faster through documents and web pages with the back or forward buttons, or even zooming in and out of photos and spreadsheets, with a flick of your finger.

Unlike any other wireless mouse, Logitech boasts 7 customizable buttons, such as the side to side-scrolling with extra controls at your fingertips.

These buttons let you navigate, create faster and easier operation, and point-and-click precision.

You won’t ever have to stress yourself about your mouse being low on power, as this item has a smart sleep mode and runs on batteries with at least 2 years!

Turning the spotlight to its advanced optical tracking feature, you can enjoy precise cursor control and responsive tracking, on just about any surface.

When plugged into your computer, the mouse connects to a nano receiver which connects to any USB port, which makes the connection and movement smooth.

Did I forget to mention? The sound of the mouse is very soft, just like it’s whispering, up to the point you won’t be able to tell if the power is on or not.

The ergonomic grip of the piece, plus its polished surface, makes it more comfortable for users with large hands.

What are you waiting for? – From what I can tell, it’s certainly a great purchase!

Pros & Benefits:

  • Good for long usage
  • Glides easy
  • No wrist burnout
  • Quiet scroll wheel


3. Microsoft’s Sculpt Ergonomic Mouse

Microsoft sculpt

Another choice from Amazon, is Microsoft’s wireless mouse, with its advanced ergonomic design of mouse angle and height, made to place your wrist in a relaxed position.

The ‘Sculpt Ergonomic Mouse’ design of this mouse, maximizes wrist comfort while making navigation effortless and it also helps prevent the pain of repetitive stress injuries, thus, encouraging a more natural arm posture.

It’s built with the intention for use anywhere, with the absence of annoying cables.

The ‘BlueTrack Technology’ built in the mouse, combines the power of optical and the precision of a laser, for remarkable tracking on almost any surface.

It is also equipped with a Windows button, for one-touch access to the Start Menu, which made navigation simpler and faster.

This item eliminates soreness and fatigue, given it’s shaped sideways and allows a more at ease feeling, compared to other normal mice.

With different accessible buttons, it’s good to use for gaming, for casual work, for web or graphic designers, or even for CAD users.

You can undeniably say, that this item is essential!

Pros & Benefits:

  • Fits like a glove
  • A magnetic battery compartment cover
  • Decrease muscle strain
  • Compact


4. iClever’s Ergonomic Wireless Vertical Mouse

iClever's mouse
The ‘iClever’s Ergonomic Wireless Vertical Mouse’, offers you 6 buttons that are placed in all the right places, considering its functions with adjustable DPI, which provides more convenience and accuracy.

You can even ditch your mouse pad because with this computer mouse, holding it sideways will give more comfort and better grip of it.

It’s equipped with a 2.4GHz wireless transmission so, that you won’t have to worry about delays and enjoy work from anywhere, because of its wireless range of 33 feet.

The advanced stability of this mouse reduces the tip noise and gives off whisper-quiet clicks, without having to distract your colleague or anyone and it has noise reduction, which means not only its clicks are silent but also its scroll wheel too!

Molded to become a beautiful diamond pattern, the 60-degree angle provides maximum comfort, that prevents your palm from becoming sweaty after a long time of use.

You can consider this item as a savior, for the reason that your hands stay when you’re holding it, without having to use extra pressure from your fingers.

This is a bit more solid with more weight, however, it still maintains its reliable click response and still responds quickly, from the battery-saving mode.

It’s one of the most highly recommended products of ergonomic mouses, considering the pain that it alleviates and the convenience it contributes while using it.

Don’t be hesitant to try this one out too!

Pros & Benefits:

  • Skin-friendly surface materials
  • Secured grip
  • Smooth clicks and slides
  • Access buttons with ease


5. TeckNet’s Bluetooth Wireless Mouse

Tecknet mouse
What’s better than a wireless mouse? A Bluetooth mouse, that can connect directly to Bluetooth-enabled laptops or computer desks, without the need for a receiver!

TeckNet is the right brand for you, as its Bluetooth wireless mouse has a ‘Tru-Wave’ sensor technology, that maintains a precise, smarter cursor control over many surface types.

You don’t need a transceiver, just empty your USB port and you’re ready to go.

With up to 2 years of battery life capacity, it’s ‘Intelligent Power Saving’ (IPS) function, is put to use.

When the mouse is not used for 3 seconds, 10 seconds, or even for 8 minutes, it will auto turn to first, second, and third levels of IPS respectively, to help reduce power consumption, allowing you to continue for a longer time.

But wait there’s more! It has a battery indicator light when the mouse has reached its maximum battery life, eliminating the worry, that your mouse would get low very early.

The durability and quality of material used in making this item, won’t let you down, as the mouse is well-built and weighs less, with a weight of 3 ounces only.

The ergonomic design and modern appearance, allows you to use it daily with its rubberized sides, made for a more tense free grip and better control of the mouse.

Enjoy smooth tracking with 5 adjustable DPI levels up to 26000 DPI, and 2 additional app-switching buttons if, you want to quickly switch between programs or move from page to page on the web, through the use of forwarding or backward buttons.

Some of the highlights of this wireless mouse are its high precision, quick response without any lag or random pointer movement, and can work immediately after connecting into your computer.

Another benefit of the mouse having no dongle is, that it won’t take up much space in your laptop case, and you won’t feel uneasy trying to carry it everywhere.

Pros & Benefits:

  • Easy to reach buttons
  • Quick pairing to computers
  • Excellent battery life
  • Lightweight perfect for travel use


6. Aurtec’s Rechargeable and Wireless Ergonomic Vertical Mouse

Aurtec's mouse
This product is designed for left-handed people, which can eliminate pressure in the wrist joint and reduce the risk of cramp.

Scientifically designed to alleviate pressure in your arm, and encourages healthy neutral “handshake” arm positions, for smoother movement and less overall strain.

It contains a high-capacity built-in rechargeable battery, so you would no longer need to buy batteries made for increased output and never-ending usage, and thanks to its auto sleeping function, it has made it easier to save energy.

You can stay online longer than you used to, since, it keeps your hand in a calm and painless position, yet you can still glide the mouse effortlessly without any trouble at all.

Consistent tracking, clicking, and scrolling are just some of the best features of the item, which is perfect when entering a lot of data, using Photoshop and any other programs, that need mastery for details.

It’s a lifesaver for left-handed people who may have carpal tunnel syndrome, which lessens the discomfort in your wrist, palm, or your whole arm when using a vertical mouse regularly.

Compared to a regular mouse, it’s ideal for daily use, because it has a thumb rest, and grips fit on the palm of your hands.

Trust me, it’s worth the price!

Pros & Benefits:

  • Extreme precision
  • Broad compatibility
  • Plug and play mouse
  • Eliminates ergonomic problems


7. Elecom’s Wireless Trackball Mouse

Elecom's mouse
This mouse can be your perfect go-to item when you want not just 1 button but 6 buttons, that provide comfort when web page browsing, internet surfing, gaming, and for people who work at length in front of the computer.

Another win for left-handed people, ‘Elecom’s M-XT4DRBK’s Wireless Trackball Mouse’ is scientifically designed, to focus on the 6 skeletal structures and muscles of your hands, which provides a better grip.

Don’t worry about cleaning the trackball, as it’s very easy to remove the ball from the back hole and you can already clean it quickly.

The ball size is only 34mm, with a diameter of 25mm, like a quarter coin, so you won’t get conscious about its dimensions.

It also has a support ball that helps prevent dirt or film during activity.

There you go! A low-maintenance and uncomplicated way of keeping it neat.

This trackball that has a high-performance optical sensor, which provides faster pin-point accuracy while moving, turning, and aiming.

Partnered with Omron Company for durable, long-lasting switches, the company made the highly reliable left and right buttons, and a pulse tilt wheel, that allows horizontal or side-to-side scroll when working on a spreadsheet.

You can easily install the ‘Elecom Mouse Assistant’, wherein you can customize each button to your desired function.

Did you notice that it’s an effortless operation, to control the 6 buttons without the need to put too much pressure when pressing them, alongside the feature of having a perfect frame of your hands?

Elecom’s Wireless Trackball Mouse is one of a kind in the market now!

Pros & Benefits:

  • Multiple options for sensitivity
  • Adjustable wireless signal strength
  • Solid battery life
  • Fast switching


8. Nulaxy’s Ergonomic Vertical Mouse

Nulaxy's mouse
If you primarily work with computers or a professional gamer on that, Nulaxy is perfect for you!

Another mouse that has a multipurpose 6 buttons, you have more control over your computer’s systems.

Be it about dragging files, selecting large volumes of data, gaming, or casual work, it brings you a low-cost and effective solution for multiple computing needs.

Just thinking of another vertical mouse may give you a long time for adjustments, but ‘Nulaxy’s Ergonomic Vertical Mouse’, is best known for its ease of holding, that combines a sleek and easy handshake grip.

The ‘thumbs-up’ position is what makes this product stand out, and help your arm move more freely, in contrast to the position of the standard flat mouse.

The handy, and advanced back and forward functionality buttons, can make ‘web page’ browsing a piece of cake.

It has an adjustable DPI setting, which will allow you to switch between 800 to 1600 DPI.

This is more beneficial to gamers, who use a higher screen resolution, with a mouse that has a higher max DPI setting.

Additionally, it is made up of a rubbery matte finish, and it has a premium feel to it, that sports an elegant look, yet nice grip while preventing fingerprints and smudges on the surface.

Its nano receiver can be stowed inside the wireless mouse when not in use, which will conserve the life of the mouse without consuming too much battery.

One-of-a-kind item with incomparable mobility best for gaming use, it presents less signal loss or lag between the mouse and the receiver, which results in a polished maneuver.

This item is suitable for both casual and gaming use! Need I say more?

Pros & Benefits:

  • Spot on button placements
  • Sturdy material
  • Fewer thumb cramps
  • Non-slip grip


9. J-Tech Digital’s Ergonomic Vertical Wired Mouse

J-tech mouse
The first wired mouse that made it into this list is the ‘J-Tech Digital Scroll Endurance Mouse’, which has an unparalleled design, with a removable palm rest, to relieve your hand and wrist from pain, helping you achieve better forearm support.

You can avoid dragging your wrist and creating friction with your hands, without further putting a strain on your bones, after a few hours of work.

You’ll feel a lined surface in your palm, that prevents your hand from slipping.

If you’re familiar with a joystick, it has the same feeling of holding a vertical mouse, but it lessens wrist soreness and refrains from getting more finger joint problems.

The ‘Scroll Endurance by J-Tech Digital’, also has adjustable sensitivity when using different applications, which can be changed using the driver free 3-mode DPI buttons on the mouse.

The multiple DPI selection for tracking gives you the option to go across multiple monitors, and adjust the speed in any way you want.

The placements of the DPI buttons are reachable and you can make sure you don’t hit it accidentally anytime.

It may take a few days of adjustments, taking into account that it has a wire but with practice, and with a few trials of trying to adapt to a new form of a mouse, you’ll grab it easily in no time!

You can take note that J-Tech Digital has a wider range of sizes and other products for left-handed models on that matter.

Pros & Benefits:

  • No special software to install
  • Plenty of room between the thumb and forefinger
  • Responsive scroll wheel
  • Minimal learning curve


10. Evoluent’s Ergonomic Vertical Wired Mouse

Evoluents's mouse
The second wired mouse in this list is ‘Evoluent’s Ergonomic VM4R Vertical Mouse’, which gently supports your right hand in an upright neutral position. 

This exceptional design has a broader lip along the bottom edge, that prevents the pinky finger from rubbing the table, to provide you optimum comfort.

You can easily program your mouse to your needs, change the function, and set how the buttons work within different programs.

By installing the ‘Evoluent Mouse Manager’, you can configure them to perform nearly any function, such as copy or paste with fewer clicks and movements, lower screen’s brightness by just rolling the mouse wheel and pressing a button at the same time.

This item is the intersection of class, comfort, and functionality.

It’s sleek yet very easy to use, even with six buttons to give you improved control over your computer’s systems.

The optical sensor control on the side of the mouse gives the power to adjust the pointer speed, from low to high, without the need to release your grip.

The hyper scrolling feature of this mouse increases sensitivity, per notch, when you roll the wheel quickly through pages.

The history of Evoluent will make you believe, that this brand perseveres, and deserves recognition, for having more than 5 vertical mouse products it can present.

Pros & Benefits:

  • Versatile device
  • Endless programming options
  • Long-lasting item
  • Futuristic design


Final Thoughts

Each product is designed to suit different preferences but one thing’s for sure, all the items listed here offer you real comfort and better productivity.

You don’t have to buy the most expensive, and most luxurious ergonomic mouse for large hands, to prove that it’s flawless and up-to-date.

The most important factor you should always keep in mind is, that it can provide you the necessary properties for everyday activities, even when you’re going to use it for a long period.

If it’s up to your liking and fit for everyday use, any mouse that has several purposes, or one that focuses more on assistance and satisfaction, is something to go for.

Now, all the best choices are laid out for you and you can never go wrong with any of them!

We hope you enjoyed reviewing this list with us, we love to hear from you, so feel free to reach out to us in the section below.

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